Shikonin derivative containing fluorine carboxylic acid ester and synthetic method and application thereof

The invention belongs to the technical field of chemical pharmacy, particularly relates to preparation of a derivative containing fluorine carboxylic acid ester and application of the derivative in tumor inhibition. The ester derivative is obtained by intriducing fluorocarboxylic acid in shikonin fr...

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Bibliographische Detailangaben
Hauptverfasser:	HAORIQINBATU, LIU HONGCHANG, LIN HONGYAN, SHI JING, WANG XIAOMING, KONG WENYAO, YANG YONGHUA, QI JINLIANG
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention belongs to the technical field of chemical pharmacy, particularly relates to preparation of a derivative containing fluorine carboxylic acid ester and application of the derivative in tumor inhibition. The ester derivative is obtained by intriducing fluorocarboxylic acid in shikonin framework molecules through a synthetic method. An in-vitro antitumor activity study shows that the derivative containing the fluorocarboxylic acid has strong inhibition activity to tumor cell lines.