Prodrug Anti-cancer Therapy

Compositions and methods for inhibiting the growth of cancer cells are provided. The cancer cells, the growth of which is inhibited, have constitutively active AbI tyrosine kinase activity due to a t(9; 22)(q34; ql 1) translocation which results in expression of a chimeric Bcr-Abl protein which has...

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Bibliographische Detailangaben
Hauptverfasser:	LEE KELVIN, CARLSON LOUIS
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compositions and methods for inhibiting the growth of cancer cells are provided. The cancer cells, the growth of which is inhibited, have constitutively active AbI tyrosine kinase activity due to a t(9; 22)(q34; ql 1) translocation which results in expression of a chimeric Bcr-Abl protein which has constitutively active AbI tyrosine kinase activity that is believed to play an important role in leukemogenesis. The compositions include a modified protein kinase C (PKC) which has an AbI tyrosine kinase target motif. The methods involve administering the modified PCK to an individual to inhibit the growth of cancer cells that have AbI tyrosine kinase activity.