2-cyclopropyl-4-substituted-phenoxy-quinoline derivatives, and its preparation method, intermediate and application
The invention discloses 2-cyclopropyl-4-substituted-phenoxy-quinoline derivatives as represented by formula A, and its preparation method, intermediate and application. The 2-cyclopropyl-4-substituted phenoxy-quinoline derivatives provided in the invention have good activity in inhibiting HMG-CoA re...
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| creator | LIN KUAILE ZHOU WEIDENG ZHOU XIAOTIAN ZHAO SHIKUI MAO LIGUANG CAI ZHENGYAN |
| description | The invention discloses 2-cyclopropyl-4-substituted-phenoxy-quinoline derivatives as represented by formula A, and its preparation method, intermediate and application. The 2-cyclopropyl-4-substituted phenoxy-quinoline derivatives provided in the invention have good activity in inhibiting HMG-CoA reductase and can be used for preparing medicines which can inhibit HMG-CoA reductase or treat diseases related to hyperlipidemia. In formula A, R1 is H or halogen, R2 is H, halogen, C1-C4 alkoxy groups or a group as represented by formula Q, R3 is H, halogen, or a group as represented by formula Q, and R4 is a group as represented by formula Q, wherein, in formula Q, R is H, halogen, C1-C4 alkyl groups or C1-C4 alkoxy groups. |
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The 2-cyclopropyl-4-substituted phenoxy-quinoline derivatives provided in the invention have good activity in inhibiting HMG-CoA reductase and can be used for preparing medicines which can inhibit HMG-CoA reductase or treat diseases related to hyperlipidemia. In formula A, R1 is H or halogen, R2 is H, halogen, C1-C4 alkoxy groups or a group as represented by formula Q, R3 is H, halogen, or a group as represented by formula Q, and R4 is a group as represented by formula Q, wherein, in formula Q, R is H, halogen, C1-C4 alkyl groups or C1-C4 alkoxy groups.</description><language>chi ; eng</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2012</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120530&DB=EPODOC&CC=CN&NR=102477032A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20120530&DB=EPODOC&CC=CN&NR=102477032A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LIN KUAILE</creatorcontrib><creatorcontrib>ZHOU WEIDENG</creatorcontrib><creatorcontrib>ZHOU XIAOTIAN</creatorcontrib><creatorcontrib>ZHAO SHIKUI</creatorcontrib><creatorcontrib>MAO LIGUANG</creatorcontrib><creatorcontrib>CAI ZHENGYAN</creatorcontrib><title>2-cyclopropyl-4-substituted-phenoxy-quinoline derivatives, and its preparation method, intermediate and application</title><description>The invention discloses 2-cyclopropyl-4-substituted-phenoxy-quinoline derivatives as represented by formula A, and its preparation method, intermediate and application. The 2-cyclopropyl-4-substituted phenoxy-quinoline derivatives provided in the invention have good activity in inhibiting HMG-CoA reductase and can be used for preparing medicines which can inhibit HMG-CoA reductase or treat diseases related to hyperlipidemia. In formula A, R1 is H or halogen, R2 is H, halogen, C1-C4 alkoxy groups or a group as represented by formula Q, R3 is H, halogen, or a group as represented by formula Q, and R4 is a group as represented by formula Q, wherein, in formula Q, R is H, halogen, C1-C4 alkyl groups or C1-C4 alkoxy groups.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2012</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyrEKwjAURuEuDqK-Q9wbqG2hsxTFycm9xOYXL6TJNbkt9u2V4gM4HTh86yyVup97FzgGnp2udRrvSUhGgdX8hA_vWb9G8sGRh7KINBmhCSlXxltFkhRHsInfG7waIM9gc0VeEAdYMoIFGmZH_YK22ephXMLu1022P59u7UWDQ4fEpoeHdO31UJR10xRVeaz-MR_ID0Vd</recordid><startdate>20120530</startdate><enddate>20120530</enddate><creator>LIN KUAILE</creator><creator>ZHOU WEIDENG</creator><creator>ZHOU XIAOTIAN</creator><creator>ZHAO SHIKUI</creator><creator>MAO LIGUANG</creator><creator>CAI ZHENGYAN</creator><scope>EVB</scope></search><sort><creationdate>20120530</creationdate><title>2-cyclopropyl-4-substituted-phenoxy-quinoline derivatives, and its preparation method, intermediate and application</title><author>LIN KUAILE ; ZHOU WEIDENG ; ZHOU XIAOTIAN ; ZHAO SHIKUI ; MAO LIGUANG ; CAI ZHENGYAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_CN102477032A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>chi ; eng</language><creationdate>2012</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LIN KUAILE</creatorcontrib><creatorcontrib>ZHOU WEIDENG</creatorcontrib><creatorcontrib>ZHOU XIAOTIAN</creatorcontrib><creatorcontrib>ZHAO SHIKUI</creatorcontrib><creatorcontrib>MAO LIGUANG</creatorcontrib><creatorcontrib>CAI ZHENGYAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LIN KUAILE</au><au>ZHOU WEIDENG</au><au>ZHOU XIAOTIAN</au><au>ZHAO SHIKUI</au><au>MAO LIGUANG</au><au>CAI ZHENGYAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>2-cyclopropyl-4-substituted-phenoxy-quinoline derivatives, and its preparation method, intermediate and application</title><date>2012-05-30</date><risdate>2012</risdate><abstract>The invention discloses 2-cyclopropyl-4-substituted-phenoxy-quinoline derivatives as represented by formula A, and its preparation method, intermediate and application. The 2-cyclopropyl-4-substituted phenoxy-quinoline derivatives provided in the invention have good activity in inhibiting HMG-CoA reductase and can be used for preparing medicines which can inhibit HMG-CoA reductase or treat diseases related to hyperlipidemia. In formula A, R1 is H or halogen, R2 is H, halogen, C1-C4 alkoxy groups or a group as represented by formula Q, R3 is H, halogen, or a group as represented by formula Q, and R4 is a group as represented by formula Q, wherein, in formula Q, R is H, halogen, C1-C4 alkyl groups or C1-C4 alkoxy groups.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 2-cyclopropyl-4-substituted-phenoxy-quinoline derivatives, and its preparation method, intermediate and application |
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