2-cyclopropyl-4-substituted-phenoxy-quinoline derivatives, and its preparation method, intermediate and application

2-cyclopropyl-4-substituted-phenoxy-quinoline derivatives, and its preparation method, intermediate and application

The invention discloses 2-cyclopropyl-4-substituted-phenoxy-quinoline derivatives as represented by formula A, and its preparation method, intermediate and application. The 2-cyclopropyl-4-substituted phenoxy-quinoline derivatives provided in the invention have good activity in inhibiting HMG-CoA re...

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Bibliographische Detailangaben
Hauptverfasser: LIN KUAILE, ZHOU WEIDENG, ZHOU XIAOTIAN, ZHAO SHIKUI, MAO LIGUANG, CAI ZHENGYAN
Format: Patent
Sprache:chi ; eng
Schlagworte:
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention discloses 2-cyclopropyl-4-substituted-phenoxy-quinoline derivatives as represented by formula A, and its preparation method, intermediate and application. The 2-cyclopropyl-4-substituted phenoxy-quinoline derivatives provided in the invention have good activity in inhibiting HMG-CoA reductase and can be used for preparing medicines which can inhibit HMG-CoA reductase or treat diseases related to hyperlipidemia. In formula A, R1 is H or halogen, R2 is H, halogen, C1-C4 alkoxy groups or a group as represented by formula Q, R3 is H, halogen, or a group as represented by formula Q, and R4 is a group as represented by formula Q, wherein, in formula Q, R is H, halogen, C1-C4 alkyl groups or C1-C4 alkoxy groups.