Quinoline derivative as well as preparation method thereof, midbody and application thereof

The invention discloses a quinoline derivative shown as a formula A as well as a preparation method thereof, a midbody and an application thereof, wherein X is O, S or N(CH3), R1 is OCH3 or halogen, R2 is H or F, and R is H or halogen or alkyl or alkoxy. The quinoline derivative has good activity fo...

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Bibliographische Detailangaben
Hauptverfasser:	DING ZICHUN, SUN GUIFANG, TANG JIEYING, ZHOU WEIDENG, CAI ZHENGYAN, YAO ZHENGWEI
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention discloses a quinoline derivative shown as a formula A as well as a preparation method thereof, a midbody and an application thereof, wherein X is O, S or N(CH3), R1 is OCH3 or halogen, R2 is H or F, and R is H or halogen or alkyl or alkoxy. The quinoline derivative has good activity for inhibiting HMG-CoA reductase and can be used for preparing medicine for inhibiting the HMG-CoA reductase or treating hyperlipidemia relevant diseases.