Process for the production of fused, tricyclic sulfonamides

Process for the production of fused, tricyclic sulfonamides

The present invention provides methods, i.e., scalable or large-scale processes for the production of fused, tricyclic sulfonamido analogs, such as substituted or unsubstituted 5- (aryl-sulfonyl)-4,5-dihydro- 1H-pyrazolo[4,3-c]quinolines and 5-(heteroaryl-sulfonyl)-4,5- dihydro-1H-pyrazolo[4,3-c]qui...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: LATIMER LEE H, PROBST GARY, MATUNAS ROBERT M, DAPPEN MICHAEL S, GODFREY JOLLIE DUAINE JR, DRABB THOMAS W, JAGODZINSKI JACEK J, WU JING
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present invention provides methods, i.e., scalable or large-scale processes for the production of fused, tricyclic sulfonamido analogs, such as substituted or unsubstituted 5- (aryl-sulfonyl)-4,5-dihydro- 1H-pyrazolo[4,3-c]quinolines and 5-(heteroaryl-sulfonyl)-4,5- dihydro-1H-pyrazolo[4,3-c]quinolines. Exemplary methods of the invention include an intra-molecular cyclization step, in which a carbon-nitrogen bond is formed, and which employs a copper-based catalyst that contains at least one organic ligand, such as DMEDA. The invention further provides compounds, which are useful as intermediates in the methods of the invention