3 - substituted allylic ester oxindole and preparation method thereof

The invention discloses 3 - substituted allylic ester oxindole and a preparation method thereof. Under the action of organic bases of n-butyl lithium or potassium bis(trimethylsilyl)amide (KHMDS) and the like, 3 - substituted oxindole and 3 - (1 - imidazolyl) methyl acrylate are subjected to an addition-elimination reaction to obtain the 3 - substituted allylic ester oxindole. In the invention, a quaternary carbon atom is successfully built, and simultaneously, a class of novel oxindole is synthesized for the first time. The compound can be used for synthesis of an active ingredient physostigmine of medicinal plants and other natural products by structural modification, a new way for artificially synthesizing a large number of physostigmine is opened, and the 3 - substituted allylic ester oxindole has a practical application value.