Applications of beta-lactamase in improving functional protein folding and preparation of fusion protein

Applications of beta-lactamase in improving functional protein folding and preparation of fusion protein

The invention provides applications of beta-lactamase or peptide of which the identity is at least 20% with a beta-lactamase amino acid sequence as leading peptide in improving functional protein folding. One or more of resectable amino acid residues in a leader sequence used in the invention are sa...

Ausführliche Beschreibung

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Bibliographische Detailangaben
1. Verfasser: LENG CHUNSHENG
Format: Patent
Sprache:chi ; eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The invention provides applications of beta-lactamase or peptide of which the identity is at least 20% with a beta-lactamase amino acid sequence as leading peptide in improving functional protein folding. One or more of resectable amino acid residues in a leader sequence used in the invention are same with one or more resectable amino acid residues of an isolated leader sequence and a to-be-folded protein precursor, which is good for resecting leader sequence segments after folding, thus the purification steps at the down stream can be simplified, and also the leader protein provided by the invention can improve the folding of functional protein.