Method for preparing quinoxaline compounds and benzimidazole compounds
The invention discloses a method for preparing quinoxaline compounds shown in formula (I) and benzimidazole compounds shown in formula (II), which comprises the following steps: reacting allenic compounds shown in formula (III) in an inert organic solvent at 25-90 DEG C for 1-48 hours under the acti...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses a method for preparing quinoxaline compounds shown in formula (I) and benzimidazole compounds shown in formula (II), which comprises the following steps: reacting allenic compounds shown in formula (III) in an inert organic solvent at 25-90 DEG C for 1-48 hours under the action of a catalyst, protonic acid and water; then adding oxalic acid and o-phenylenediamine, and reacting at 50-120 DEG C for 1-24 hours; and after the reaction, carrying out post treatment on the reaction liquid to obtain the quinoxaline compounds shown in formula (I) and the benzimidazole compoundsshown in formula (II), wherein the catalyst is triphenyl gold chloride and silver tetrafluoroborate; the protonic acid is concentrated sulfuric acid, and methanesulfonic acid or p-toluenesulfonic acid or trifluoroacetic acid; and the inert organic solvent is an organic solvent which can not react with the allenic compounds. By using the one-pot method to prepare the quinoxaline compounds, the invention has the advantages |
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