Diaryl diene cyclic ketone derivatives, and preparation method and application thereof

Diaryl diene cyclic ketone derivatives, and preparation method and application thereof

The invention discloses diaryl diene cyclic ketone derivatives, and a preparation method and application thereof. The chemical formula of the derivatives is shown as the formula (I). The diaryl diene cyclic ketone derivatives have a structure similar to that of natural curcumin, are more stable than...

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Hauptverfasser: A.H.KONNE, TU ZENGQING, LU YUJING, HUANG BAOHUA, ZHENG XI, XUE GUIHUA, DU ZHIYUN, WEI XINGCHUAN, TANG ZHIKAI, XU XUETAO, FANG YANXIONG, ZHANG KUN, MO RONGQING, HUANG HUARONG
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention discloses diaryl diene cyclic ketone derivatives, and a preparation method and application thereof. The chemical formula of the derivatives is shown as the formula (I). The diaryl diene cyclic ketone derivatives have a structure similar to that of natural curcumin, are more stable than the curumin, easy to synthesize and suitable for expanded production. The diaryl diene cyclic ketone derivatives have good inhibition effects on the proliferation growth of various tumor cells such as humanized prostatic cancer cells, pancreatic cancer cells, colon cancer cells and the like, low toxic and side effects and a prospect of being developed into a novel anti-tumor medicament.