Isomerization method

The present invention relates to a method for preparing a trans-1,4-disubstituted cyclohexane compound with at least one benzene-derived residue at 1- or 4- position. The method comprises an isomerization step for converting one or a plurality of cis-configured cyclohexane ring to trans configuratio...

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Bibliographische Detailangaben
Hauptverfasser: WAECHTLER ANDREAS DR, KRIEGBAUM MARKUS, MAILLARD DAVID DR, SCHAEFER RALF, KRATTIGER PHILIPP DR
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The present invention relates to a method for preparing a trans-1,4-disubstituted cyclohexane compound with at least one benzene-derived residue at 1- or 4- position. The method comprises an isomerization step for converting one or a plurality of cis-configured cyclohexane ring to trans configuration in the presence of additional compound which forms carbocations while a strong acid is used.