Construction method of operation model for collecting cerebrospinal fluid repeatedly

The invention discloses a construction method of an operation model for collecting cerebrospinal fluid repeatedly, comprising the following steps: positioning an operation drilling hole on the planar structure of an animal skull; puncturing into the drilling hole by an external sleeve puncturing needle; burying and fixing a flow guiding pipe; and collecting the cerebrospinal fluid for repeatedly by the flow guiding pipe. The method provides a new model for collecting the cerebrospinal fluid in a more effective and reasonable manner for a pharmacological experiment of toxic generation and pharmacological generation and the like. According to the method, the survival rate of operation of the animal can reach 80%, the success rate of the model can reach 60%, and thus the construction method of the model is reasonable in design, and is beneficial to collecting the cerebrospinal fluid repeatedly.