Oral controlled release tablet with reduced burst effect

The present invention refers to an oral controlled release tablet providing a reduced risk of alcohol induced dose dumping; said tablet comprising: a core comprising a first compressed layer comprising a swelling agent, a second compressed layer comprising at least one therapeutically active ingredi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: DHARMADHIKARI NITIN BHALACHANDRA, ZALA YASHORAJ RUPSINGH
Format: Patent
Sprache:chi ; eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The present invention refers to an oral controlled release tablet providing a reduced risk of alcohol induced dose dumping; said tablet comprising: a core comprising a first compressed layer comprising a swelling agent, a second compressed layer comprising at least one therapeutically active ingredient, and pharmaceutically acceptable excipient wherein at least one excipient is a release rate controlling excipient and wherein the percent by weight of excipients that are soluble in alcohol does not exceed 35 % by weight of the layer, optionally a third compressed layer comprising a swelling agent; and a coating surrounding the said core, the coating comprising a polymer insoluble in an aqueous medium comprising from 0 % v/v to 40 % v/v of alcohol, whereby upon contact with aqueous gastrointestinal fluids, the upper compressed layer swells to cause removal of the coating from the upper surface of the upper compressed layer and then said upper layer disintegrates allowing the release of the active ingredient fro