Method for preparing nanoliposomes by supercritical CO2 fluid

The invention discloses a method for preparing nanoliposomes by supercritical CO2 fluid, which comprises the following steps of: (1) dissolving a certain amount of lipid membrane materials and cosurfactant into supercritical CO2 in a supercritical reaction kettle, and solubilizing a certain amount of distilled water to form a supercritical micro-emulsion; (2) pre-expanding the supercritical micro-emulsion under set pressure and temperature and then rapidly jetting into a water phase medium in a supercritical collection kettle through a nozzle at a certain flow velocity, and dispersing and settling out to form liposome mixed suspension liquid; and (3) continuously dissolving CO2 through the supercritical collection kettle and removing residual ethanol in the liposome mixed suspension liquid, metering by a rotor metering gauge and evacuating, and collecting the liposome mixed suspension liquid in the supercritical collection kettle. In the technology, the micro-emulsion of the lipid membrane materials formed in