Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones

Bicyclic nitroimidazoles covalently linked to substituted phenyl oxazolidinones

The current invention provides a series of bicyclic nitroimidazole-substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatm...

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Bibliographische Detailangaben
Hauptverfasser: PALMER BRIAN DESMOND, SUTHERLAND HAMISH SCOTT, MA ZHENKUN, DING ZHAOZHONG, BLASER ADRIAN, THOMPSON ANDREW M, DENNY WILLIAM ALEXANDER, SONG MINSOO, LU GENLIANG, KMENTOVA IVETA, CHEN DIAJUN D, COMBRINK KEITH, WANG JIANCHENG
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The current invention provides a series of bicyclic nitroimidazole-substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatment of bacterial infections. The bicyclic nitroimidazole-substituted phenyl oxazolidinones possess surprising antibacterial activity against wild-type and resistant strains of pathogens, and are therefore useful for the prevention, control and treatment of a number of human and veterinary bacterial infections caused by these pathogens, such as Mycobacterium tuberculosis.