Method for preparing imipenem

Method for preparing imipenem

The invention discloses a method for preparing imipenem, comprising the following steps: 1) a bicyclic nucleus III undergoes phosphorylation to obtain an intermediate IV, after the intermediate IV directly reacts with cysteamine hydrochloride without separation, a solvent G is added to obtain solven...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HUANG HUAYONG, WANG XIAOHUA, SHANG WANLI, CHEN CHONGHONG, ZHANG YANJUN, LIU SHAOXIONG, MO SHENGHUA, GUO JINGNING, REN PENG, ZHU XIZONG, OU PENG, LI HAO
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention discloses a method for preparing imipenem, comprising the following steps: 1) a bicyclic nucleus III undergoes phosphorylation to obtain an intermediate IV, after the intermediate IV directly reacts with cysteamine hydrochloride without separation, a solvent G is added to obtain solvent inclusion VI, wherein the solvent G is selected from one or more of chloroalkanes, nitriles, alcohols and esters; and 2) the solvent inclusion VI and imine benzyl ester undergo condensation to obtain an intermediate VII and the intermediate VII directly undergoes catalytic hydrogenation without separation to obtain imipenem I.