Method for preparing imipenem
The invention discloses a method for preparing imipenem, comprising the following steps: 1) solvent inclusion VI and imine benzyl ester undergo condensation to obtain an intermediate VII, wherein the solvent of the solvent inclusion is selected from one or more of pyrrolidones, amides, chloralkanes,...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses a method for preparing imipenem, comprising the following steps: 1) solvent inclusion VI and imine benzyl ester undergo condensation to obtain an intermediate VII, wherein the solvent of the solvent inclusion is selected from one or more of pyrrolidones, amides, chloralkanes, nitriles, alcohols and esters; and 2) the intermediate VII directly undergoes catalytic hydrogenation without separation to obtain imipenem I. |
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