Topical fluorouracil vesicle gel and preparation method thereof

The invention relates to a fluorouracil vesicle gel which is prepared by using fluorouracil, PlronicF68, Span and other surfactants, cholesterols and the like to prepare vesicle suspension in the self-assembly way, and further using carbomer and other excipients to prepare the vesicle gel, and the fluorouracil vesicle gel can be topically applied o the skin for treating various viral warts, keratosis, skin cancer, psoriasis, keloid, melanoma and other diseases. The prepared vesicle has complete shape and relatively uniform particle size distribution, and the encapsulation rate is 23.48%-51.14%. The vesicle gel has good uniformity and stable nature, and excised skin test results of rats and mice prove that the vesicle gel can significantly increase the retention of a drug in the skin and have the sustained release property, indicating that the fluorouracil vesicle gel has high utilization rate of the drug in the topical part of medication and significant sustained release effect of a drug storage library, and