Preparation method of sulfonanilide compound

The invention discloses a preparation method for a sulfonanilide compound, which comprises the following steps: adding 1-10 parts by mol of an aprotic dipolar solvent into a reactor, raising the temperature of the reactor to 90-136 DEG C while stirring, adding 0.001-0.1 part by mol of a catalyst, stirring the mixture, dropping 1-10 parts by mol of a sulfonated agent and carrying out a sulfonylation reaction for 10-25h at 90-136 DEG C, and cooling, filtering, washing and baking the reaction product, then obtaining the sulfonanilide compound. The catalyst adopted by the invention is triphenylphosphine, polyethylene glycol or crown ether instead of the former expensive catalysts including tetrabutyl amonium bromide and DMF, while the reaction conversion rate is above 99%, the reaction effectis better, the side reactions are less, and high-purity products are obtained in high yield. With simple technique, low cost of catalyst and few side reactions, the invention is suitable for large-scale industrial production.