Puerarin self-microemulsion composition based on mixed oil and preparation method thereof

The invention discloses a puerarin self-microemulsion composition, which consists of puerarin, mixed oil, an emulsifier and an auxiliary emulsifier by weight percent, wherein the puerarin accounts for 0.5-5 percent; the mixed oil accounts for 36-61 percent; the emulsifier accounts for 10-50 percent; and the auxiliary emulsifier accounts for 5-30 percent. The puerarin self-microemulsion composition prepared in the invention not only solves the problems of the traditional emulsion such as large particle size, and poor stability, large storage volume and the like due to existence of the aqueous phase, but also improves the solubility and dispersion of puerarin, increases the in vivo absorption of drugs, and enhances the bioavailability. The invention has the advantages of low viscosity, stable quality and the like, and can improve the drug absorption, enhance the bioavailability and reduce the toxic and side effects.