Preparation method of cefetamet pivoxil hydrochloride

The invention relates to a preparation method of cefetamet pivoxil hydrochloride. The method comprises the preparation of ceftamet and the cefetamet pivoxil hydrochloride and comprises the specific operation steps that 7-ADCA and AE-active ester are condensed in an organic solvent under an alkaline condition to prepare condensation compound in which the content of cefetamet is more than 99 percent; and the condensation compound prepared in the first step is reacted with an organic sodion providing body, the product is directly esterified with iodomethyl pivalate in a strong polar solvent, esterified esters and concentrated hydrochloric acid are salified in an alcohol solvent, and medical cefetamet pivoxil hydrochloride is prepared via crystallization. In the process of preparing cefetamet ester, only cefetamet is separated, sodium cefetamet is not separated for direct esterification. The synthesis process is greatly simplified, the reaction condition is milder, the raw materials are easily obtained, and the o