Application of citric acid diethyl ester in preparation of anticoagulant medicament

The invention relates to an application of a pharmaceutical grade citric acid diethyl ester used as an anticoagulant in medicament, in particular to an application in blood purification anticoagulation, belonging to the field of anticoagulation of the medicament. In research findings, the citric aci...

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Hauptverfasser: CHEN ZHAO, YAO GANGLIAN, OU YAN, LI MEIRU, GUI BAOSONG, ZAN YING
Format: Patent
Sprache:chi ; eng
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Zusammenfassung:The invention relates to an application of a pharmaceutical grade citric acid diethyl ester used as an anticoagulant in medicament, in particular to an application in blood purification anticoagulation, belonging to the field of anticoagulation of the medicament. In research findings, the citric acid diethyl ester has obvious blood calcium reducing capacity in vivo and in vitro, obvious anticoagulation effect and high dissociation speed in vivo, can fast dissociate from calcium ions, is definite in extracorporeal circulation effect, that is to say, the citric acid diethyl ester can achieve the effect without blood coagulation in vitro and hemorrhage in vivo, and also prevents the side effect possible to generate by citric acid anticoagulation after entering in vivo without metabolic alkalosis, hypernatremia, volume load increase, hypocalcemia or hypercalcemia caused by overabundant calcium supplement due to indefinite calcium supplement, thereby overcoming the defects of sodium citrate anticoagulation, solvin