Urea derivatives, preparation method and use thereof

Urea derivatives, preparation method and use thereof

The invention provides urea derivatives, which have the following general formula. In the formula, R is H or nitroso, R2 is 5-chloro-2-hydroxyphenmethyl or 3,5-dichloro-2-hydroxyphenmethyl, and R3 is p-methylphenyl, p-fluorophenyl, p-methoxyphenyl, p-chlorophenyl, p-bromophenyl, 2,4-difluorophenyl,...

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Hauptverfasser: YAN TAO, LI HUANQIU, LI QINGSHAN, ZHU HAILIANG, LUO YIN
Format: Patent
Sprache:chi ; eng
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator YAN TAO
LI HUANQIU
LI QINGSHAN
ZHU HAILIANG
LUO YIN
description The invention provides urea derivatives, which have the following general formula. In the formula, R is H or nitroso, R2 is 5-chloro-2-hydroxyphenmethyl or 3,5-dichloro-2-hydroxyphenmethyl, and R3 is p-methylphenyl, p-fluorophenyl, p-methoxyphenyl, p-chlorophenyl, p-bromophenyl, 2,4-difluorophenyl, 2-chlorophenyl, 2-(N-morpholinyl)ethyl, 3-(N-morpholinyl)propyl, n-dodecylamino, n-hexadecylamino or n-octadecylamino. The urea derivatives have an obvious inhibiting effect on the cancer cell strain (KB) of the epicuticle of human oral cavity and human leukemia cell strain (K562). Thus, the urea derivatives can be applied to the preparation of antineoplastic drugs. The invention discloses a preparation method of the urea derivatives.
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Urea derivatives, preparation method and use thereof
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