Urea derivatives, preparation method and use thereof

The invention provides urea derivatives, which have the following general formula. In the formula, R is H or nitroso, R2 is 5-chloro-2-hydroxyphenmethyl or 3,5-dichloro-2-hydroxyphenmethyl, and R3 is p-methylphenyl, p-fluorophenyl, p-methoxyphenyl, p-chlorophenyl, p-bromophenyl, 2,4-difluorophenyl, 2-chlorophenyl, 2-(N-morpholinyl)ethyl, 3-(N-morpholinyl)propyl, n-dodecylamino, n-hexadecylamino or n-octadecylamino. The urea derivatives have an obvious inhibiting effect on the cancer cell strain (KB) of the epicuticle of human oral cavity and human leukemia cell strain (K562). Thus, the urea derivatives can be applied to the preparation of antineoplastic drugs. The invention discloses a preparation method of the urea derivatives.