Application of long effective curcumin derivative in preparing anti-depression drug

The invention relates to an application of a long effective curcumin derivative in preparing an anti-depression drug. The long effective curcumin derivative is an ester which is formed in such a way that C1 to C50 saturated or unsaturated fatty acids or acyls thereof react with hydroxyl groups of curcumin substances by esterification respectively and independently. Through the research on the anti-depression action of various animal models, the long effective curcumin derivative can reserve the inherent anti-depression drug effect of the curcumin and also has the effects of the slow release and the prolongation of the drug effect and a favorable prospect of clinical application. The long effective curcumin derivative can be also used for preparing anti-depression drinks, foods, food addiitives or health products.