Preparation method of small unilamellar vesicle liposome of ivermectin

The invention discloses a preparation method of small unilamellar vesicle liposome of ivermectin, and relates to a preparation method of ivermectin liposome, which solves the problems that the existing ivermectin preparation has short effective date, and needs to deliver drug repeatedly and the sustained release macro-pill of the ivermectin has high toxicity. The method comprises the following steps of: adding raw ivermectin powder in organic solution of soya bean lecithin and cholesterol, then carrying out pressure reduction, rotation and evaporation to the obtained injectable suspension tilla layer of thin film is formed at the inner wall of a reactor, then dissolving the thin film in PBS solution, adding glass beads into a rotary-type oscillator, shaking to wash the film for 1 hour, then standing for 1 hour, and carrying out ultrasonic oscillation so as to obtain the small unilamellar vesicle liposome of ivermectin. The liposome obtained by the preparation method has similar structure as a biofilm, can be