Genetic marker and chip for forecasting risks of diabetes nephropathy and application thereof

The invention discloses a method for detecting Chinese diabetics who suffer nephropathy or have the possibility to suffer nephropathy or are suspected to suffer nephropathy. The method comprises the following steps: detecting whether a sample from a diabetic contains an I/D genotype of an ACE gene,...

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Bibliographische Detailangaben
Hauptverfasser:	SU YONGYI, CHEN ZHONGE, WU CHUXIAN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention discloses a method for detecting Chinese diabetics who suffer nephropathy or have the possibility to suffer nephropathy or are suspected to suffer nephropathy. The method comprises the following steps: detecting whether a sample from a diabetic contains an I/D genotype of an ACE gene, an M235T genotype of an AGT gene, a (CA) n-5' (z-2) genotype of an ALR2 gene; a C106T genotype of an ALR2 gene promoter area, a G-308A genotype of a TNF-a gene and at least one polymorphism sequence of complementary polymorphism sequences. The ALR2 genotype is not used signally, and the existence of the polymorphism sequences indicates that the diabetic suffers nephropathy or has the possibility to suffer nephropathy or is suspected to suffer nephropathy. The invention also provides a chip for detecting Chinese diabetics who suffer nephropathy or have the possibility to suffer nephropathy or are doubtful to suffer nephropathy.