Peptide vaccine for animal and preparation method thereof

The invention provides an aftosa synthetic peptide vaccine, more specifically to polypeptide for aftosa synthetic peptide vaccine, vaccine containing the polypeptide and a preparation method thereof. The polypeptide has amino acid sequence represented by SEQ ID NO.1, SEQ ID NO.2, SEQ ID NO.3, SEQ ID...

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Bibliographische Detailangaben
Hauptverfasser:	LI LIFANG, LI BINGSHOU, QI PENG, XIAO JIN
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Beschreibung
Zusammenfassung:	The invention provides an aftosa synthetic peptide vaccine, more specifically to polypeptide for aftosa synthetic peptide vaccine, vaccine containing the polypeptide and a preparation method thereof. The polypeptide has amino acid sequence represented by SEQ ID NO.1, SEQ ID NO.2, SEQ ID NO.3, SEQ ID NO.4, SEQ ID NO.5 and SEQ ID NO.6. By sequencing of recent aftosa strain in China and combination of aftosa vaccine strain sequence, the invention researches variation case of main antigen site, carries out antigen site analysis and forecast assisted by computer, and carries out chemical synthesis to possible antigen site peptide segment. The invention screens polypeptide antigen through a large amount of animal tests, optimizes aftosa virus antigen site according to screening result, effectively combines T cell epitope and B cell epitope, and enhances immunization effect of the polypeptide antigen. The aftosa synthetic peptide can effectively reply antigenic variation of the aftosa virus, has good biological safe