Process for preparing a crystalline form of candesartan cilexetil

A process for preparing a crystalline form of candesartan cilexetil referred to as Form I, which has a content of Form II lower than 1% (w/w), is described. The process comprises a seeding stage with a crystalline product, which mainly comprises Form I, and a digestion stage. The invention also rela...

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Bibliographische Detailangaben
Hauptverfasser:	COSME GOMEZ ANTONIO, RODRIGUEZ SALGADO NATIVIDAD, PALOMO NICOLAU FRANCISCO EUGEN, VICIOSO SANCHEZ MERCEDES, GONZALEZ HERNANDEZ PEDRO
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A process for preparing a crystalline form of candesartan cilexetil referred to as Form I, which has a content of Form II lower than 1% (w/w), is described. The process comprises a seeding stage with a crystalline product, which mainly comprises Form I, and a digestion stage. The invention also relates to said crystalline form, the pharmaceutical compositions containing it and its use for the preparation of a medicament for the treatment of hypertension. Candesartan cilexetil Form I has shown good stability under accelerated stability conditions, when the content of Form II is lower than 1% w/w.