Fusion protein of human parathyrine (1-34) diad and human seralbumin and preparation thereof
The invention relates to a fusion protein of human parathyrine (1-34) diad and human seralbumin and a preparation technology thereof, belonging to the technical field of long lasting recombinant fusion protein. The fusion protein comprises the first region of the diad which has at least 85% homologo...
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| creator | ZHANG MEI CHU MIN ZHU RUIYU FU QIANG ZHANG LIANFEN JIN JIAN CHEN YUN WU MINCHEN LI YING |
| description | The invention relates to a fusion protein of human parathyrine (1-34) diad and human seralbumin and a preparation technology thereof, belonging to the technical field of long lasting recombinant fusion protein. The fusion protein comprises the first region of the diad which has at least 85% homologous sequence with the human parathyrine (1-34) and the second region which has at least 85% homologous sequence with the human seralbumin. Using overlapping PCR technology twice, firstly two h PTH (1-34) are spliced to obtain the diad, and secondly the diad and H AS are spliced together without any connecting peptide. The fusion protein can replace, delete or add in respective amino acid residue under the premise that the feature of the fusion protein is not changed, prominently extends the half life period in human body based on the condition that the function of the human parathyrine for activating receptor and irritating bone remodeling is retained, and is the medicinal fusion protein which is used for curing ost |
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The fusion protein comprises the first region of the diad which has at least 85% homologous sequence with the human parathyrine (1-34) and the second region which has at least 85% homologous sequence with the human seralbumin. Using overlapping PCR technology twice, firstly two h PTH (1-34) are spliced to obtain the diad, and secondly the diad and H AS are spliced together without any connecting peptide. The fusion protein can replace, delete or add in respective amino acid residue under the premise that the feature of the fusion protein is not changed, prominently extends the half life period in human body based on the condition that the function of the human parathyrine for activating receptor and irritating bone remodeling is retained, and is the medicinal fusion protein which is used for curing ost</description><language>chi ; eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2009</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20091014&DB=EPODOC&CC=CN&NR=101555482A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20091014&DB=EPODOC&CC=CN&NR=101555482A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ZHANG MEI</creatorcontrib><creatorcontrib>CHU MIN</creatorcontrib><creatorcontrib>ZHU RUIYU</creatorcontrib><creatorcontrib>FU QIANG</creatorcontrib><creatorcontrib>ZHANG LIANFEN</creatorcontrib><creatorcontrib>JIN JIAN</creatorcontrib><creatorcontrib>CHEN YUN</creatorcontrib><creatorcontrib>WU MINCHEN</creatorcontrib><creatorcontrib>LI YING</creatorcontrib><title>Fusion protein of human parathyrine (1-34) diad and human seralbumin and preparation thereof</title><description>The invention relates to a fusion protein of human parathyrine (1-34) diad and human seralbumin and a preparation technology thereof, belonging to the technical field of long lasting recombinant fusion protein. 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The fusion protein comprises the first region of the diad which has at least 85% homologous sequence with the human parathyrine (1-34) and the second region which has at least 85% homologous sequence with the human seralbumin. Using overlapping PCR technology twice, firstly two h PTH (1-34) are spliced to obtain the diad, and secondly the diad and H AS are spliced together without any connecting peptide. The fusion protein can replace, delete or add in respective amino acid residue under the premise that the feature of the fusion protein is not changed, prominently extends the half life period in human body based on the condition that the function of the human parathyrine for activating receptor and irritating bone remodeling is retained, and is the medicinal fusion protein which is used for curing ost</abstract><oa>free_for_read</oa></addata></record> |
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| language | chi ; eng |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | Fusion protein of human parathyrine (1-34) diad and human seralbumin and preparation thereof |
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