Fusion protein of human parathyrine (1-34) diad and human seralbumin and preparation thereof

The invention relates to a fusion protein of human parathyrine (1-34) diad and human seralbumin and a preparation technology thereof, belonging to the technical field of long lasting recombinant fusion protein. The fusion protein comprises the first region of the diad which has at least 85% homologous sequence with the human parathyrine (1-34) and the second region which has at least 85% homologous sequence with the human seralbumin. Using overlapping PCR technology twice, firstly two h PTH (1-34) are spliced to obtain the diad, and secondly the diad and H AS are spliced together without any connecting peptide. The fusion protein can replace, delete or add in respective amino acid residue under the premise that the feature of the fusion protein is not changed, prominently extends the half life period in human body based on the condition that the function of the human parathyrine for activating receptor and irritating bone remodeling is retained, and is the medicinal fusion protein which is used for curing ost