Chemical synthesis method of 2-acylamino-3-biphenyl propionic acid

The invention relates to a chemical synthesis method of a 2-acylamino-3-biphenyl propionic acid, and the reaction equation is shown as following, wherein X is chlorine, bromine, iodine, methylsulfonylor tosyl; R1 is methyl, ethyl, propyl, isopropyl, butyl, isobutyl, tert-butyl or benzyl; HY is hydrochloric acid, formic acid, acetic acid, citric acid, oxalic acid, tartaric acid, sulfuric acid, nitric acid or phosphoric acid; R2 is methyl, ethyl, propyl, isopropyl, benzyl or 4-chlorobenzyl. Preferably, the R1 prefers to ethyl or isobutyl; HY prefers to hydrochloric acid; and R2 prefers to ethyl. The invention has short route, simple operation, high reagent selectivity, low production cost, high production purity and high yield, is suitable for large-scale industrial production, and has larger economic and social benefits.