Cross-linked hyaluronic acid gel and preparation method thereof

Cross-linked hyaluronic acid gel and preparation method thereof

The invention provides a cross-linked hyaluronic acid gel and a preparation method thereof. A preparation contains cross-linked hyaluronic acid and uncrosslinked hyaluronic acid, and the cross-linked hyaluronic acid is prepared by reacting a cross-linking agent and hyaluronic acid molecules to form...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MAO ZHENQIN, HOU YONGTAI, ZHU CHENG, KONG SHUJING
Format: Patent
Sprache:chi ; eng
Schlagworte:
AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G
CHEMISTRY
COMPOSITIONS BASED THEREON
COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
GENERAL PROCESSES OF COMPOUNDING
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
THEIR PREPARATION OR CHEMICAL WORKING-UP
USE OF INORGANIC OR NON-MACROMOLECULAR ORGANIC SUBSTANCES ASCOMPOUNDING INGREDIENTS
WORKING-UP
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Beschreibung
Zusammenfassung:The invention provides a cross-linked hyaluronic acid gel and a preparation method thereof. A preparation contains cross-linked hyaluronic acid and uncrosslinked hyaluronic acid, and the cross-linked hyaluronic acid is prepared by reacting a cross-linking agent and hyaluronic acid molecules to form the cross-linked hyaluronic acid gel in the alkaline environment, and then removing the cross-linking agent. The cross-linked hyaluronic acid gel has excellent biocompatibility and long half-life, and is suitable for tissue filling, bone joint lubricating or medicament slow-releasing preparation, and the like.