A process for the manufacture of snac (n-(8-[2-hydroxybenzoyl]-amino) salcaprozate sodium)

A process for the manufacture of snac (n-(8-[2-hydroxybenzoyl]-amino) salcaprozate sodium)

Disclosed are improved methods for the synthesis of N-(8-[2-hydroxybenzoyl]- amino) caprylic acid. Certain compounds have been found useful for preventing the formation of a colored impurity when included in an ester hydrolysis reaction. Conducting ester hydrolysis in anaerobic conditions has also b...

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Bibliographische Detailangaben
Hauptverfasser: BERNADINO JOSEPH NORMAN, KLEIN GEORGE FREDERICK, REN YI, BAY WILLIAM ELLIOTT, ZHANG PINGSHENG
Format: Patent
Sprache:chi ; eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Disclosed are improved methods for the synthesis of N-(8-[2-hydroxybenzoyl]- amino) caprylic acid. Certain compounds have been found useful for preventing the formation of a colored impurity when included in an ester hydrolysis reaction. Conducting ester hydrolysis in anaerobic conditions has also been found to minimize the formation of the color impurity. Also disclosed are improved methods for synthesizing the sodium salt of N-(8-[2-hydroxybenzoyl]-amino) caprylic acid.