Administration of the reg1 anticoagulation system

An improved method of administration of an aptamer and antidote system to regulate blood coagulation in a host is provided based on weight adjusted or body mass index-adjusted dosing of the components of the system to provide a desired pharmacodynamic response. In addition, a method of reversing act...

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Bibliographische Detailangaben
Hauptverfasser: TONKENS ROSS M, RUSCONI CHRISTOPHER P
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:An improved method of administration of an aptamer and antidote system to regulate blood coagulation in a host is provided based on weight adjusted or body mass index-adjusted dosing of the components of the system to provide a desired pharmacodynamic response. In addition, a method of reversing activity of the aptamer to a desired extent is provided where an antidote dose is based solely on its relationship to the aptamer dose.