Methods of treating degenerative disorders with RAC 1B inhibitor

The invention relates to compositions and methods for treating degenerative disorders. More particularly, the invention relates to methods of treating amyloid beta peptide-related disorders, particularly Alzheimer's disease, using Rac1b inhibitors. The invention may be used in mammalian subjects, particularly human subjects, at various stages of the disease, including disease onset. The invention also provides methods of producing, identifying, selecting or optimising compounds for use in the treatment of amyloid beta peptide-related disorders, based on a determination of the ability of a test compound to inhibit Rac1b.