Compositions comprising amphotericin B

Compositions comprising amphotericin B

A composition includes particles including at least about 95 wt% of amphotericin B, wherein the particles have a mass median diameter ranging from about 1.1 [mu]m to about 1.9 [mu]m. Another composition also includes particles including at least about 95 wt% of amphotericin B, wherein at least about...

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Bibliographische Detailangaben
Hauptverfasser: MALCOLMSON RICHARD, SWEENEY THERESA, DUDDU SARMA, MILLER DANFORTH, FRANTZ CHRISTOPHER, WASHCO KEITH, PALAKODATY SRINIVAS, DWIVEDI SARVAJNA, TAN TRIXIE
Format: Patent
Sprache:chi ; eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:A composition includes particles including at least about 95 wt% of amphotericin B, wherein the particles have a mass median diameter ranging from about 1.1 [mu]m to about 1.9 [mu]m. Another composition also includes particles including at least about 95 wt% of amphotericin B, wherein at least about 80 wt% of the particles have a geometric diameter ranging from about 1.1 [mu]m to about 1.9 gm. Yet another composition includes particles including amphotericin B, wherein the particles have a mass median diameter less than about 1.9 [mu]m, and wherein the amphotericin B has a crystallinity levelof at least about 20%. Unit dosage forms, delivery systems, and methods may involve similar compositions.