Zero-order modified release solid dosage forms

The invention comprises a solid dosage form for delivery of water soluble pharmaceutical agents. The solid dosage form comprises a matrix core containing the pharmaceutical agent and a hydrophobic material, and a coating containing a hydrophilic pore-forming agent and a hydrophobic polymer. The dosa...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MEADOWS JUSTIN CLARK, RASTOGI SUNEEL KUMAR, GUPTA VISHAL KUMAR
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention comprises a solid dosage form for delivery of water soluble pharmaceutical agents. The solid dosage form comprises a matrix core containing the pharmaceutical agent and a hydrophobic material, and a coating containing a hydrophilic pore-forming agent and a hydrophobic polymer. The dosage form exhibits a zero-order release profile upon dissolution.