Etretinate type medicine solid dispersion

The invention relates to an aromatic tretinoin medicament compound, in particular to a solid dispersoid which can improve the dissolution rate and the dissolution degree of aromatic tretinoin as well as the amine salt and ester medicaments thereof. The invention takes a strongly hydrophilic high mol...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: JIANG SHIMAO, LIU JUNSHENG
Format: Patent
Sprache:chi ; eng
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Beschreibung
Zusammenfassung:The invention relates to an aromatic tretinoin medicament compound, in particular to a solid dispersoid which can improve the dissolution rate and the dissolution degree of aromatic tretinoin as well as the amine salt and ester medicaments thereof. The invention takes a strongly hydrophilic high molecular compound, a surface active agent or an organic acid compound as a dispersing vector to prepare the aromatic tretinoin medicament into the solid dispersoid. The dispersoid can be prepared into a plurality of preparations which can be used on clinic. Test approves that the prepared solid dispersoid can effectively improve the dissolution rate and the external dissolution degree of the aromatic tretinoin medicament.