Two-liquid phase fermentation method for improving paclitaxel yield from fungi

The invention relates to a method for improving the yield of taxol produced from fungi by two-liquid phase fermentation, which comprises the following steps: a fungus Pestalotiopsis microspora NK17 used to produce the taxol is cultured in a culture medium; when a thallus grows to a plateau phase, an...

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Bibliographische Detailangaben
Hauptverfasser:	ZHU XUDONG, PAN JIAO, LIU ZHIPENG, BI JIANNAN, YAN BING
Format:	Patent
Sprache:	chi ; eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PROCESSES USING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to a method for improving the yield of taxol produced from fungi by two-liquid phase fermentation, which comprises the following steps: a fungus Pestalotiopsis microspora NK17 used to produce the taxol is cultured in a culture medium; when a thallus grows to a plateau phase, an organic solvent is added to continue the culture to ensure that the taxol is more produced and gathered in strain cells and the culture medium; and the taxol is recovered from the cells and culture medium and is purified. The method has high taxol yield, low production cost and short fermentation period, and is applied to industrial production; and the yield of the taxol can be trebled.