Method for preparing MICA

Method for preparing MICA

The invention discloses a method for preparing (Z)-2-(tert-Methoxycarbonyl Methoxyimino)-2-(2-Aminothiazol-4-yl)Acetic Acid, which uses diketene as starting material that is chloridized and esterified to obtain 4-chloro-acetyl-tert-butyl acetate, an intermediate product; then the intermediate produc...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: SUN YANLI, LIU GANG, HOU LEWEI, ZHAO YEQING, SUN BIN
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention discloses a method for preparing (Z)-2-(tert-Methoxycarbonyl Methoxyimino)-2-(2-Aminothiazol-4-yl)Acetic Acid, which uses diketene as starting material that is chloridized and esterified to obtain 4-chloro-acetyl-tert-butyl acetate, an intermediate product; then the intermediate product is nitrosated, alkylated, cyclized and hydrolyzed to obtain the (Z)-2-(tert-Methoxycarbonyl Methoxyimino)-2-(2-Aminothiazol-4-yl)Acetic Acid. The method adopts a phase transfer catalysis technique, thus reducing technical steps, simplifying operation, shortening reaction period, reducing production cost, reducing pollution of the three wastes and having super high industrial application value.