Method for solid phase polypeptide synthesis of hexarelin

The invention relates to a preparation method of hexarelin, and mainly solves the technical problems with long synthetic period and applications of hypertoxic substances in the prior synthetic method. The method for synthesizing the hexarelin by adopting the solid phase polypeptide synthetic method comprises the steps as follows: Fmoc-Linker-AM-Resin or Fmoc-Linker-MBHA-Resin is adopted as the initial raw material; amino acids with Fmoc protective groups are sequentially connected according to the solid phase polypeptide synthetic method to obtain a protected six peptide resin, while the Fmocprotective groups are sequentially removed and a peptide synthetic reaction is carried out in the presence of one of DIC/HOBt, DIC/HOAt, BOP/HOBt, BOP/HOAt, HBTU/HOBt, HBTU/HOAt, HATU/HOBt, HATU/HOAtor HCTU/HOBt as a condensing agent; side chain protective groups removal and peptide cutting are carried out synchronously to obtain a coarse product; the coarse product is subjected to separation and purification to obtain th