PROCESS FOR THE PREPARATION THERAPEUTIC AGENTS AND THEIR USE

Compounds of formula Iand pharmaceutically acceptable salts thereof; in which R, and R2, which are the same or different, are H or an optionally substituted hydrocarbon group or R, and R2 together with the nitrogen atom to which they are attached form an optionally substituted heterocyclic ring;R3 is an optionally substituted aromatic hydrocarbon group; andR4 is a hydrocarbon group containing at least one substituent selected from the group consisting of hydroxy and acylated derivatives thereof, optionally substituted alkoxy groups, optionally substituted cycloalkyloxy groups, optionally substituted alkylenedioxy groups, oxo and groups of formula S(O)pR5 in which p is 0, 1 or 2 and R5 is an alkyl group, said hydrocarbon group being optionally substituted by additional substituents,are useful in the treatment of depression.