Sustained-release agent containing tuberculosis-resistance medicament

The invention relates to a slow-release implant or a slow-release injection containing antituberculotic drug(s), which can be locally placed on or injected into tuberculosis foci to slowly release the antituberculotic drug(s), so as to effectively obtain and keep effective drug concentration at local foci and at the same time reduce the systemic toxicity of the drug. The slow-release injection comprises slow-release microspheres and a solvent, wherein the slow-release microspheres comprise slow-release adjuvants and antituberculotic drug(s) selected from cycloserine, ofloxacin, ciprofloxacin and/or sparfloxacin; the solvent is a special solvent containing a suspending agent; the suspending agent has viscosity of 100-3,000cp (at 20-30 DEG C) and is selected from sodium carboxymethyl cellulose, etc.; the slow release adjuvants are selected from EVAc, polifeprosan, polylactic acid (PLA), polys(lactic-co-glycolic acid) (PLGA), poly(erucic acid dimmer-sebacic acid or fumaric acid-sebacic acid) copolymers, etc.; an