Novel method for splitting and producing natural (-)-huperzine and non- natural (+)-huperzine by racemate of diastereoisomer salt
The invention discloses a new making method of (-)-Huperzine and non-natural Huperzine detached from racemate of diastereoisomer salt, which comprises the following steps: forming diastereoisomer saltthrough chemically synthesized racemic O-methyl-Huperzine and (-)-2,3-dibenzoyl-L-tartaric acid to f...
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Format: | Patent |
Sprache: | chi ; eng |
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Zusammenfassung: | The invention discloses a new making method of (-)-Huperzine and non-natural Huperzine detached from racemate of diastereoisomer salt, which comprises the following steps: forming diastereoisomer saltthrough chemically synthesized racemic O-methyl-Huperzine and (-)-2,3-dibenzoyl-L-tartaric acid to form diastereoisomer salt; recrystallizing and purifying through organic solvent; obtaining the needed pure diastereoisomer salt; obtaining (-)-O-methyl-Huperzine after liberating; obtaining the product through deprotecting reaction; using (+)-2,3-dibenzoyl-D-tartaric acid as antimorph of acid detaching agent to make the non-natural (+)-Huperzine through the same steps. |
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