Inhibitors of AKT activity

The instant invention provides for canthine analogs that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by admini...

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Bibliographische Detailangaben
1. Verfasser: LINDSLEY CRAIG W.,LEISTER WILLIAM H.,BOGUSKY MICHAEL J.,BARNETT STANLEY F
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The instant invention provides for canthine analogs that inhibit Akt activity. In particular, the compounds disclosed selectively inhibit one or two of the Akt isoforms. The invention also provides for compositions comprising such inhibitory compounds and methods of inhibiting Akt activity by administering the compound to a patient in need of treatment of cancer.