Aryl-amino substituted pyrrolopyrimidine multi-kinase inhibiting compounds

Aryl-amino substituted pyrrolopyrimidine multi-kinase inhibiting compounds

Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mekl, PDK-1, GSK3ss, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-lR, Ron, Ret, and KDR kinases in anima...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: AHMED SALEH,BARBA OSCAR,BLOXHAM JASON,DAWSON GRAHAM,GATTRELL WILIAM,KITCHIN JOHN,PEGG NEIL ANTHONY,SABA IMAAD,SADIQ SHAZIA,SAMBROOK SMITH COLIN PETER,SMYTH DON,STEING AMO G.,WILKES ROBIN,PANICKER BIJO, G HANQING,MA LIFU,FOREMAN KENNETH,WENG QINGHUA,STOLZ KATHRYN
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Compounds represented by Formula (I): or stereoisomers or pharmaceutically acceptable salts thereof, are inhibitors of least two of the Abl, Aurora-A, Blk, c-Raf, cSRC, Src, PRK2, FGFR3, Flt3, Lck, Mekl, PDK-1, GSK3ss, EGFR, p70S6K, BMX, SGK, CaMKII, Tie-2, IGF-lR, Ron, Ret, and KDR kinases in animals, including humans, for the treatment and/or prevention of various diseases and conditions such as cancer.