Cyclopamine analogues and methods of use thereof

The present invention provides compositions and methods for modulating smootheneddependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gai...

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Bibliographische Detailangaben
1. Verfasser:	ADAMS JULIAN,CASTRO ALFREDO C.,FOLEY MICHAEL A.,JANARDANAN NAIR SOMARAJAN N.,NEVALAINEN MARTA,PORTER JAMES R.,TREMBLAY MARTIN R
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	The present invention provides compositions and methods for modulating smootheneddependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-offunction mutations. The compounds of the present invention are particularly useful in treating cancers.