HIV inhibiting 1.2.4-triazin-6-one derivates

HIV inhibiting 1.2.4-triazin-6-one derivates

The present invention relates to HIV replication inhibitors of formula (I), N-oxide thereof, pharmaceutically acceptable addition salt, quaternary ammonium or stereochemistry isomeric form, in which ring A and B represent phenyl, pyridinyl, pyridazinyl, pyrimidinyl or pyrazinyl; n and m are 1-4; R1...

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Bibliographische Detailangaben
Hauptverfasser: LEWI PAULUS JOANNES, VINKERS HENDRIK MAARTEN, DAEYAERT FREDERIK F. D, HEERES JAN, KOYMANS LUCIEN MARIA H, KILONDA AMURI, JANSSEN PAUL ADRIAAN JAN, DE JONGE MARC RENE, HOORNAERT GEORGES J. C
Format: Patent
Sprache:chi ; eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to HIV replication inhibitors of formula (I), N-oxide thereof, pharmaceutically acceptable addition salt, quaternary ammonium or stereochemistry isomeric form, in which ring A and B represent phenyl, pyridinyl, pyridazinyl, pyrimidinyl or pyrazinyl; n and m are 1-4; R1 represents hydrogen, aryl, formacyl, C1-6 alkyl carbonyl, C1-6 alkoxycarbonyl, optionally substituted C1-6 alkyl, C1-6 alkoxy C1-6 alkyl carbonyl subtituted by C1-6 alkoxycarbonyl. The invention also discloses the medical application such as treating or preventing the HIV infection, their producing method and the medicine composition.