2-amino-quinazoline derivatives useful as inhibitors of beta-secretase (BACE)

The present invention is directed to novel 2-amino-3, 4-dihydroquinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of P-secretase, also known as n-sit...

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Bibliographische Detailangaben
Hauptverfasser:	RIA ALOYSIUS,REITZ ALLEN B, BAXTER ELLEN,BISCHOFF FRANCOIS PAUL,BOYD ROBERT,BRAEKEN MIRIELLE,COATS STEVEN,HUANG YIFANG,JORDAN ALFONZO,LUO CHI,MERCKEN MARC HUBERT,REYNOLDS CHARLES H.,ROSS TINA MORGAN,TOUNGE BRETT A.,SCHULZ MARK,D
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention is directed to novel 2-amino-3, 4-dihydroquinazoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of P-secretase, also known as n-site cleaving enzyme and BACE.